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THE ROENTGEN RADIATION OF PAPILLOMA VIRUS (SHOPE) : I. THE EFFECT OF X-RAYS UPON PAPILLOMAS ON DOMESTIC RABBITS
J T Syverton1, R A Harvey, G P Berry
1Departments of Bacteriology and Medicine (Radiology), University of Rochester, School of Medicine and Dentistry, Rochester, New York.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Roentgen ray therapy effectively treats virus-induced papillomas in rabbits. A dose of 3600 r uniformly eliminates Shope papillomas, while 3000 r cures 60% of tumors.
Area of Science:
- Oncology
- Veterinary Medicine
- Radiation Biology
Background:
- Virus-induced papillomas, also known as Shope papillomas, are common skin tumors in domestic rabbits.
- These papillomas can cause significant cosmetic and health issues for affected animals.
Purpose of the Study:
- To investigate the efficacy of Roentgen ray (X-ray) therapy for treating Shope papillomas in rabbits.
- To determine the optimal radiation dosage for complete and permanent tumor eradication.
Main Methods:
- Domestic rabbits with virus-induced papillomas were subjected to varying doses of Roentgen rays.
- Radiation was administered either as a single dose or fractionally.
- Tumor response was evaluated based on complete disappearance and permanence.
Main Results:
- A uniform dose of 3600 r (delivered at 200 kilovolts) resulted in the complete and permanent disappearance of Shope papillomas.
- Fractional administration of the 3600 r dose yielded similar results to single administration.
- A dose of 3000 r achieved a cure rate of 60% for the tumors.
Conclusions:
- Roentgen ray therapy is a viable and effective treatment for virus-induced papillomas in rabbits.
- The determined dosage of 3600 r provides a reliable method for achieving complete tumor resolution.
- Fractional dosing can be considered for treating these papillomas, offering flexibility in treatment protocols.
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