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A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
STUDIES ON EXPERIMENTAL HYPERTENSION : XIV. THE EFFECT OF INTERMITTENT RENAL ARTERIAL OCCLUSION ON THE BLOOD PRESSURE
H Goldblatt1, H Weinstein, J R Kahn
1Institute of Pathology, Western Reserve University, Cleveland.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Intermittent renal artery occlusion in dogs did not cause persistent hypertension. Only severe, prolonged constriction or occlusion led to high blood pressure and kidney insufficiency, refuting theories of brief ischemia causing chronic hypertension.
Area of Science:
- Nephrology
- Cardiovascular Physiology
Background:
- Renal artery constriction is a known cause of hypertension.
- The role of transient renal ischemia in chronic hypertension is debated.
Purpose of the Study:
- To investigate if intermittent renal ischemia can induce persistent hypertension.
- To determine the effects of varying degrees of renal artery occlusion on blood pressure and renal function.
Main Methods:
- Unilaterally nephrectomized dogs underwent daily intermittent renal arterial occlusion for up to 5 months.
- Persistent moderate and severe renal artery constriction models were also employed.
Main Results:
- Intermittent occlusion did not elevate blood pressure.
- Persistent moderate constriction caused hypertension without significant renal impairment.
- Severe constriction or occlusion led to rapid hypertension and renal insufficiency (malignant phase).
Conclusions:
- Brief, intermittent renal ischemia does not appear to cause persistent hypertension of renal origin.
- Sustained renal artery compromise is necessary for the development of renovascular hypertension and renal insufficiency.
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