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Related Experiment Video

Updated: Jun 19, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

QUANTITATIVE CHEMICAL STUDIES ON COMPLEMENT OR ALEXIN : I. A METHOD.

M Heidelberger¹

¹Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York.

The Journal of Experimental Medicine

|October 30, 2009

Summary

This summary is machine-generated.

A new quantitative micro method estimates complement levels in milligrams per milliliter, offering improved accuracy and reproducibility over traditional volume units for complement analysis.

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Area of Science:

Biochemistry
Analytical Chemistry
Immunology

Background:

Complement analysis traditionally uses variable volume units.
Accurate quantification of complement is crucial for understanding immune responses and disease states.

Purpose of the Study:

To introduce a novel quantitative micro method for complement estimation.
To establish a more precise and standardized approach using mass concentration units.

Main Methods:

Development of a quantitative micro assay.
Application of analytical chemistry principles for method validation.

Main Results:

The proposed method allows complement estimation in milligrams per milliliter.
Demonstrated accuracy and reproducibility of the new quantitative micro method.

Conclusions:

The new method provides a standardized and accurate way to quantify complement.
This advancement in complement analysis facilitates more reliable research and diagnostics.