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Related Concept Videos

Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...

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Updated: Jun 19, 2026

Whole Body Vibration Methods with Survivors of Polio
04:16

Whole Body Vibration Methods with Survivors of Polio

Published on: October 17, 2018

SECOND ATTACKS OF POLIOMYELITIS : AN EXPERIMENTAL STUDY.

H A Howe1, D Bodian

  • 1Department of Anatomy, Johns Hopkins University, Baltimore.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary
This summary is machine-generated.

Poliomyelitis virus in rhesus monkeys showed restricted spread, with second attacks depending on virus strain and initial dissemination. Human immunity likely prevents virus entry into nervous tissue, not nervous system immunization.

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Area of Science:

  • Virology
  • Neuroscience
  • Immunology

Background:

  • Poliomyelitis virus can cause paralysis by infecting specific neuronal systems.
  • Understanding viral dissemination and host immune response is crucial for vaccine development.

Purpose of the Study:

  • To investigate the spread of poliomyelitis virus within the rhesus monkey central nervous system (CNS).
  • To explore factors influencing secondary poliomyelitis attacks and their relation to immunity.

Main Methods:

  • Inoculation of rhesus monkeys with various strains of poliomyelitis virus via multiple routes (intracerebral, intranasal, etc.).
  • Observation of lesion development, paralysis, and immune response following primary and secondary infections.

Main Results:

  • Polio virus inoculation via different routes did not always result in lesions in all neural tissues, indicating restricted viral spread.
  • Convalescent monkeys showed varied responses to re-exposure, with secondary attacks influenced by virus strain and initial dissemination.
  • Secondary infections could occur even without clinical signs, suggesting subclinical immune responses.

Conclusions:

  • The rhesus monkey model presents challenges for studying human poliomyelitis immunity due to restricted viral spread.
  • Human immunity to poliomyelitis is likely achieved by preventing the virus from reaching nervous tissue, rather than through nervous system immunization.