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ORAL PAPILLOMATOSIS OF RABBITS: A VIRUS DISEASE.
1Laboratories of The Rockefeller Institute for Medical Research.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Oral papillomas in rabbits are caused by a specific virus, often transmitted from mother to young. Injury or tar exposure can activate latent virus, leading to tumor formation.
Area of Science:
- Veterinary Pathology
- Virology
- Oncology
Background:
- Oral papillomas are common in New York metropolitan area domestic rabbits.
- These benign growths primarily affect the underside of the tongue.
Purpose of the Study:
- To identify the causative agent of oral papillomas in rabbits.
- To differentiate this oral papilloma virus from the Shope papilloma virus.
- To investigate factors influencing papilloma development.
Main Methods:
- Virus extraction from papillomas and inoculation into rabbits and hares.
- Comparative inoculation studies with Shope virus.
- Observation of transmission and latency in rabbit populations.
- Experimental inoculation with virus and tar exposure.
Main Results:
- A distinct filtrable virus causes oral papillomas, reproducible in rabbit and hare oral mucosa.
- This oral papilloma virus is immunologically distinct from the Shope virus.
- Transmission occurs from mother to offspring; virus can be latent and activated by mucosal injury or tar exposure.
- Tar acts as an adjuvant, increasing papilloma incidence in virus-carrying rabbits.
Conclusions:
- A specific oral papilloma virus causes these lesions in rabbits.
- Viral latency and activation by trauma or chemical agents like tar are key to disease development.
- Understanding transmission and activation factors is crucial for managing oral papillomas in rabbits.
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