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Updated: Jun 19, 2026
09:02
Monitoring Influenza Virus Survival Outside the Host Using Real-Time Cell Analysis
Published on: February 20, 2021
THE SEDIMENTATION RATE OF THE BIOLOGICAL ACTIVITIES OF INFLUENZA A VIRUS
1Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, New Jersey.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Influenza A virus infectivity and red blood cell agglutination are linked to 100 mm particles. These findings support the association of biological activities with specific influenza virus components.
Area of Science:
- Virology
- Biophysics
Background:
- Influenza A virus exhibits multiple biological activities, including infectivity and hemagglutination.
- Understanding the physical properties of influenza virus is crucial for characterizing its infectious agents.
Purpose of the Study:
- To determine the sedimentation rates of mouse infectivity principles for PR8 and F12 influenza A virus strains.
- To correlate biological activities (infectivity and hemagglutination) with specific influenza virus components.
Main Methods:
- Sedimentation rate analysis using a separation cell.
- Assay of mouse infectivity, chicken red blood cell agglutination, and chick embryo infectivity.
Main Results:
- Sedimentation rates of mouse infectivity principles were comparable to principal components of purified influenza A virus.
- The majority of hemagglutinating activity and chick embryo infectivity sedimented at the same rate as the 100 mm component.
- Some biological activity was associated with aggregated influenza virus particles.
Conclusions:
- The study supports the association of mouse infectivity, hemagglutination, and chick embryo infectivity with the 100 mm spherical particles of influenza A virus.
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