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ANAEROBIC GLYCOLYSIS OF THE BRAIN IN EXPERIMENTAL POLIOMYELITIS

H G Wood1, I I Rusoff, J M Reiner

  • 1Department of Physiology, University of Minnesota, Minneapolis.

The Journal of Experimental Medicine
|October 30, 2009
PubMed

Insights

Poliomyelitis did not significantly alter brain anaerobic glycolysis rates in mice. Studies found no consistent changes, suggesting current enzyme analysis methods may be insufficient to determine poliomyelitis

Area of Science:

  • Neuroscience
  • Virology
  • Biochemistry

Background:

  • Poliomyelitis is a viral disease affecting the nervous system.
  • Previous studies suggested poliomyelitis interferes with brain's energy metabolism.
  • Anaerobic glycolysis is a key process for brain energy production.

Purpose of the Study:

  • To investigate the effect of experimental poliomyelitis on anaerobic glycolysis in mouse brain tissue.
  • To determine if poliomyelitis impacts brain energy metabolism.

Main Methods:

  • Comparison of anaerobic glycolysis rates in normal versus poliomyelitis-infected mice.
  • Utilized two mouse strains and two experimental procedures.
  • Calculated brain Q(CO(CO2) ) (N(2) ) based on wet weight.

Main Results:

  • No significant difference in brain anaerobic glycolysis was observed between normal and infected mice when calculated on a wet weight basis.
  • One experimental series showed a slight increase in glycolysis, while another showed a slight decrease in infected animals.
  • Previous reports of poliomyelitis interfering with brain anaerobic glycolysis were not confirmed.

Conclusions:

  • The study did not confirm interference of poliomyelitis with brain anaerobic glycolysis.
  • Current enzymatic methods may be inadequate for studying this effect.
  • Further research is needed to definitively assess poliomyelitis' impact on brain energy metabolism.

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