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Updated: Jun 19, 2026

Single-Cell Optical Action Potential Measurement in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Published on: December 22, 2020
THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : II.
1Departments of Pharmacology and Bacteriology, New York University College of Medicine, New York.
Abstract:
1. The mechanism of sensitization of the isolated frog' heart to a product of the hemolytic streptococcus has been investigated. The sensitization depends upon the release from the isolated heart of a substance which inhibits the action of the cardiotoxin. The inhibitor is released upon the first (sensitizing) administration of cardiotoxin, but not upon the second (contracture-producing) administration. 2. The inhibitor released by the heart neutralizes the lethal factor present in the streptococcal preparation employed. 3. Some of the properties of the inhibitor have been investigated.
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