Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Herpes-simplex-virus encephalitis: its possible association with reactivated latent infection.

The New England journal of medicine·2011
Same author

Effect of in vitro cultivation on the pathogenicity of West Nile virus.

Journal of bacteriology·2010
Same author

Effect of in vitro cultivation on the pathogenicity of West Nile virus.

The Journal of experimental medicine·2010
Same author

Effect of in vitro cultivation on the pathogenicity of Venezuelan equine encephalomyelitis virus.

The Journal of experimental medicine·2010
Same author

Serologic distinctness of Eastern, Western, and Venezuelan equine encephalomyelitis viruses.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)·2010
Same author

Neurosecretion; cytoplasmic inclusions in peripheral autonomic ganglion cells of the monkey.

The Anatomical record·2010

Related Experiment Video

Updated: Jun 19, 2026

Viral Concentration Determination Through Plaque Assays: Using Traditional and Novel Overlay Systems
09:28

Viral Concentration Determination Through Plaque Assays: Using Traditional and Novel Overlay Systems

Published on: November 4, 2014

INTERFERENCE BETWEEN VIRUSES IN TISSUE CULTURE.

E H Lennette1, H Koprowski

  • 1Service for Studies and Research in Yellow Fever, Rio de Janeiro, Brazil.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary
This summary is machine-generated.

The 17DD High strain of yellow fever virus inhibits the growth of other viruses, including West Nile virus and influenza A virus, in tissue cultures. This viral interference was observed in one direction only.

More Related Videos

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
11:14

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

Adenovirus-mediated Genetic Removal of Signaling Molecules in Cultured Primary Mouse Embryonic Fibroblasts
11:00

Adenovirus-mediated Genetic Removal of Signaling Molecules in Cultured Primary Mouse Embryonic Fibroblasts

Published on: September 9, 2010

Related Experiment Videos

Last Updated: Jun 19, 2026

Viral Concentration Determination Through Plaque Assays: Using Traditional and Novel Overlay Systems
09:28

Viral Concentration Determination Through Plaque Assays: Using Traditional and Novel Overlay Systems

Published on: November 4, 2014

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
11:14

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

Adenovirus-mediated Genetic Removal of Signaling Molecules in Cultured Primary Mouse Embryonic Fibroblasts
11:00

Adenovirus-mediated Genetic Removal of Signaling Molecules in Cultured Primary Mouse Embryonic Fibroblasts

Published on: September 9, 2010

Area of Science:

  • Virology
  • Cell Biology
  • Infectious Diseases

Background:

  • Viral interference is a phenomenon where one virus affects the replication of another.
  • Understanding viral interference mechanisms is crucial for developing antiviral strategies and vaccines.

Purpose of the Study:

  • To investigate the influence of one virus on the growth of another in tissue culture.
  • To determine the extent of viral interference caused by the 17DD High strain of yellow fever virus against other viruses.

Main Methods:

  • Tissue culture experiments were performed to assess viral growth.
  • Different virus strains, including yellow fever virus (17DD High and Asibi strains), West Nile virus, Venezuelan equine encephalomyelitis virus, and influenza A virus, were used.
  • Viral suppression was evaluated based on the quantity of inoculated viruses.

Main Results:

  • The 17DD High strain of yellow fever virus completely suppressed the growth of the Asibi strain of yellow fever virus and West Nile virus.
  • Both 17DD High yellow fever virus and West Nile virus partially or completely suppressed Venezuelan equine encephalomyelitis virus growth.
  • These viruses also suppressed influenza A virus growth, but reciprocal interference was not demonstrable.
  • No neutralizing antibodies or non-specific antiviral substances were detected in cultures infected with 17DD High yellow fever virus.

Conclusions:

  • The 17DD High strain of yellow fever virus exhibits significant antiviral activity against a range of viruses in vitro.
  • The observed viral interference is primarily unidirectional, with limited evidence of reciprocal effects.
  • The mechanism of interference does not appear to involve neutralizing antibodies or non-specific antiviral substances.