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Published on: September 1, 2016
THE PRODUCTION OF CHRONIC GLOMERULONEPHRITIS IN RATS BY THE INJECTION OF RABBIT ANTI-RAT-PLACENTA SERUM
1Departments of Bacteriology and of Medicine, Columbia University, and the Research Service, First (Columbia University) Division, Goldwater Memorial Hospital, Department of Hospitals, New York.
Abstract:
1. The injection of rabbit anti-rat-placenta serums in young adult rats produced chronic glomerulonephritis in 18 of 32 animals. 2. The course of the nephritis and the renal lesions were indistinguishable from those obtained in 11 of 13 animals injected with rabbit anti-rat-kidney serum. 3. Six instances of similar renal lesions occurred among 99 control animals. In 2 the rats had been injected with rabbit anti-rat-erythrocyte serum, in 2 with rabbit anti-rat-serum serum, while in 2 others the lesions were found among normal stock.
