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IMMUNITY IN MUMPS : VI. EXPERIMENTS ON THE VACCINATION OF HUMAN BEINGS WITH FORMOLIZED MUMPS VIRUS

J Stokes1, J F Enders, E P Maris

  • 1School of Medicine of the University of Pennsylvania and the Children's Hospital of Philadelphia, Philadelphia, and the Department of Bacteriology and Immunology, Harvard Medical School, and the School of Public Health, Boston.

The Journal of Experimental Medicine
|October 30, 2009
PubMed

Insights

A mumps virus vaccine derived from infected monkeys showed increased resistance in about half of the vaccinated children. This study investigated the efficacy of a novel inactivated mumps virus vaccine candidate.

Area of Science:

  • Virology
  • Immunology
  • Pediatrics

Background:

  • Mumps is a contagious viral illness.
  • Vaccination is crucial for preventing mumps outbreaks.
  • Previous mumps vaccines have varying efficacy.

Purpose of the Study:

  • To evaluate the effectiveness of a novel formol-inactivated mumps virus vaccine.
  • To assess the vaccine's ability to confer resistance against active mumps virus inoculation.

Main Methods:

  • Experimental inoculation of active mumps virus into children.
  • Administration of a vaccine prepared from formol-inactivated mumps virus.
  • Comparison of resistance levels between vaccinated and unvaccinated children.

Main Results:

  • Approximately 50% of vaccinated children demonstrated increased resistance to mumps virus.
  • The inactivated mumps virus vaccine showed partial efficacy.

Conclusions:

  • The formol-inactivated mumps virus vaccine shows potential for increasing resistance.
  • Further research is warranted to optimize mumps vaccine development and efficacy.
Keywords:
PAROTITIS/immunityVIRUSES/diseases

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