THE INACTIVATION OF TRYPSIN : IV. THE ADSORPTION OF TRYPSIN BY CHARCOAL
1Laboratories of The Rockefeller Institute for Medical Research.
The Journal of General Physiology
|October 30, 2009
Abstract:
1. Charcoal removes trypsin from solution. The amount removed depends on the order in which the solutions are mixed. The reaction is not reversible and is almost independent of the pH of the solution. 2. Charcoal which has been previously treated with gelatin does not remove trypsin from solution. 3. The reaction is not analogous either to the reaction between trypsin and the inhibiting substance of serum or to the reaction between solid protein and either pepsin or trypsin.
Related Concept Videos
Prevention of Further Absorption of Poison
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
Indirect-Acting Cholinergic Agonists: Mechanism of Action
Indirect-acting cholinergic agonists work by interacting with an enzyme called acetylcholinesterase (AChE) in the synaptic cleft. They can be reversible or irreversible inhibitors and have different effects on the enzyme.
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex, leading to...
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex, leading to...


