STUDIES ON TOXICITY

With yeast subjected to the action of phenol or of phenol and alcohol the curves of survivors as measured by resistance to staining with methylene blue when plotted against time do not in general prove to be logarithmic. It is believed that such resemblances as have been found between such curves and monomolecular reaction or logarithmic curves are superficial and fortuitous. Any method therefore of evaluating disinfecting power based upon such a concept must prove misleading. Variations in resistance of individual cells and the distribution of such variations must be regarded as of fundamental importance in accounting for rates of death of microorganisms.