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Paradigms for Pharmacological Characterization of C. elegans Synaptic Transmission Mutants
Published on: August 18, 2008
SUPPRESSION OF PHOTOTROPIC CIRCUS MOVEMENTS OF LIMAX BY STRYCHNINE
1Zoological Laboratory, Rutgers University, New Brunswick, and the Carnegie Institution of Washington.
Abstract:
By injection with strychnine the phototropic circus movements of the slug Limax maximus may be suppressed, its phototropism abolished. The creeping activity of the foot is not in any essential way interferred with. Strychnine produces in Limax central nervous effects of the sort associated with its characteristic action. Hence, although an effect of the drug upon photoreceptors cannot be definitely excluded, the experimental result is held to demonstrate that in orientation during circus movements there occurs central "competition" between impulses resulting (1) in the release of pedal waves and (2) in the maintenance of a turning posture.

