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Updated: Jun 19, 2026

A Screenable In Vivo Assay for Mitochondrial Modulators Using Transgenic Bioluminescent Caenorhabditis elegans
Published on: October 16, 2015
THE INHIBITION OF CYPRIDINA LUMINESCENCE BY LIGHT
1Physiological Laboratory, Princeton University, Princeton, and the Nela Research Laboratories, Cleveland.
Abstract:
The luminescence of Cypridina luciferin-luciferase solution is inhibited by illumination from a carbon arc of 15,000 foot candles in between 1 and 2 seconds. The blue to violet rays are the effective ones, the limits lying somewhere around 4,600 A. u. to 3,800 A. u. The luciferin, not the luciferase, is the substance affected by the light. The effect is partially reversible in the dark. The chemiluminescences obtained by oxidizing phosphorus, lophin, and chlorphenylmagnesium bromide are not inhibited by light under the above conditions.
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