Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ventricular load optimization by unloading therapy in patients with heart failure.

T Kameyama1, H Asanoi, S Ishizaka

  • 1Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.

Journal of the American College of Cardiology
|January 1, 1991
PubMed
Summary

Reducing afterload with nitroprusside improved ventricular-arterial coupling and work efficiency in heart failure patients. Conversely, reducing preload with lower body negative pressure worsened coupling and efficiency.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Linoleic acid salt with ultrapure soft water as an antibacterial combination against dermato-pathogenic Staphylococcus spp.

Journal of applied microbiology·2015
Same author

Antifungal effects of palmitic acid salt and ultrapure soft water on Scedosporium apiospermum.

Journal of applied microbiology·2013
Same author

Induction of inner ear hair cell-like cells from Math1-transfected mouse ES cells.

Cell death & disease·2013
Same author

In vitro differentiation of mouse embryonic stem cells into inner ear hair cell-like cells using stromal cell conditioned medium.

Cell death & disease·2012
Same author

Emission and metal- and ligand-centered-redox characteristics of the hexarhenium(III) clusters trans- and cis-[Re6(mu 3-S)8Cl4(L)2]2-, where L is a pyridine derivative or pyrazine.

Inorganic chemistry·2003
Same author

Reparability of lethal lesions produced by phosphorus photoabsorption in yeast cells.

Journal of radiation research·2002

Area of Science:

  • Cardiology
  • Physiology
  • Biomedical Engineering

Background:

  • Heart failure is characterized by impaired ventricular-arterial coupling.
  • Optimizing this coupling is crucial for improving cardiac function.

Purpose of the Study:

  • To investigate the effects of preload and afterload reduction on ventricular-arterial coupling in patients with heart failure.
  • To assess the impact of these interventions on left ventricular external work, end-systolic potential energy, and work efficiency.

Main Methods:

  • 13 heart failure patients underwent measurements of arterial pressure and left ventricular echocardiograms.
  • Preload was reduced using lower body negative pressure (-20 mm Hg).
  • Afterload was reduced using nitroprusside; phenylephrine was used to elevate pressure.

Related Experiment Videos

Main Results:

  • Baseline ventricular-arterial coupling (Ea/Ees ratio) was elevated (1.96 +/- 0.31).
  • Nitroprusside significantly decreased the Ea/Ees ratio to 1.45 +/- 0.22, improving work efficiency.
  • Lower body negative pressure increased the Ea/Ees ratio to 2.37 +/- 0.34, reducing work efficiency.

Conclusions:

  • Afterload reduction with nitroprusside enhances ventricular-arterial coupling and cardiac efficiency in heart failure.
  • Preload reduction with lower body negative pressure impairs coupling and efficiency.
  • These findings highlight differential effects of preload and afterload modulation on cardiac performance.