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Ex Vivo Red Blood Cell Hemolysis Assay for the Evaluation of pH-responsive Endosomolytic Agents for Cytosolic Delivery of Biomacromolecular Drugs
Published on: March 9, 2013
THE ACCELERATION OF SAPONIN HEMOLYSIS BY PROFLAVINE
1Department of Biochemistry, Dalhousie University, Halifax, N.S.
The Journal of General Physiology
|October 30, 2009
Abstract:
Proflavine is a very powerful accelerator of saponin hemolysis of rabbit, human, and dog erythrocytes. Lysolecithin hemolysis, on the other hand, is inhibited. Dog erythrocytes in the presence of proflavine undergo marked changes in shape, finally becoming rods of about 13 micro in length. Rabbit and human erythrocytes are not altered in form under these conditions.
