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Related Concept Videos

Cellular Membranes and Drug Transport01:24

Cellular Membranes and Drug Transport

Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
The Significance of Membrane Transport01:44

The Significance of Membrane Transport

The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
Facilitated Diffusion01:16

Facilitated Diffusion

The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
Facilitated Transport01:19

Facilitated Transport

The chemical and physical properties of plasma membranes cause them to be selectively permeable. Since plasma membranes have both hydrophobic and hydrophilic regions, substances need to be able to transverse both regions. The hydrophobic area of membranes repels substances such as charged ions. Therefore, such substances need special membrane proteins to cross a membrane successfully. In facilitated transport, also known as facilitated diffusion, molecules and ions travel across a membrane via...
Facilitated Transport01:19

Facilitated Transport

The chemical and physical properties of plasma membranes cause them to be selectively permeable. Since plasma membranes have both hydrophobic and hydrophilic regions, substances need to be able to transverse both regions. The hydrophobic area of membranes repels substances such as charged ions. Therefore, such substances need special membrane proteins to cross a membrane successfully. InĀ  facilitated transport, also known as facilitated diffusion, molecules and ions travel across a membrane via...
Pore Transport and Ion-Pair Transport01:17

Pore Transport and Ion-Pair Transport

Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limitedĀ  but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct microscopic...

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Related Experiment Video

Updated: Jun 19, 2026

Fluorescence Recovery after Merging a Droplet to Measure the Two-dimensional Diffusion of a Phospholipid Monolayer
07:54

Fluorescence Recovery after Merging a Droplet to Measure the Two-dimensional Diffusion of a Phospholipid Monolayer

Published on: October 15, 2015

Ion Transport through Monolayers and Interfacial Films.

I R Miller1

  • 1Department of Polymer Research, The Weizmann Institute of Science, Rehovoth, Israel.

The Journal of General Physiology
|October 30, 2009
PubMed
Summary
This summary is machine-generated.

This study explores ion transport across thin films at the mercury/water interface. It details how film properties and ion interactions influence permeability, with implications for systems like lecithin monolayers.

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Last Updated: Jun 19, 2026

Fluorescence Recovery after Merging a Droplet to Measure the Two-dimensional Diffusion of a Phospholipid Monolayer
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Published on: October 15, 2015

Temperature-Controlled Assembly and Characterization of a Droplet Interface Bilayer
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Area of Science:

  • Electrochemistry
  • Physical Chemistry
  • Surface Science

Background:

  • Understanding ion transport across interfaces is crucial for various electrochemical applications.
  • Monolayers and thin films significantly influence interfacial processes.
  • Lecithin monolayers present unique challenges due to weak ion binding.

Purpose of the Study:

  • To investigate ion transport mechanisms through monolayers and thin films at the mercury/water interface.
  • To develop a model describing ion permeability as a function of film properties.
  • To analyze the factors contributing to the activation energy of ion transport.

Main Methods:

  • Theoretical modeling of ion transport kinetics.
  • Analysis of rate constants (k(c)) using absolute rate theory.
  • Examination of film thickness, diffusion coefficient, and distribution coefficient effects.
  • Consideration of electrostatic interactions and monolayer compression work.

Main Results:

  • Ion permeability through monolayers is governed by a rate constant (k(c)).
  • Permeability through thicker films depends on film thickness, diffusion, and distribution coefficients.
  • Activation energy for ion transport includes electrostatic, compression, and boundary line formation terms.
  • Lecithin monolayers exhibit weak ion binding, complicating transport and retarding oxygen reduction.

Conclusions:

  • Ion transport is modulated by film properties and interfacial interactions.
  • The model provides a framework for understanding ion passage through thin films.
  • Lecithin's unique properties impact ion transport and electrochemical reactions at interfaces.