[Preparation and in vitro release of Maiyanning sustained-release patches]
1Pharmaceutical Department, Beijing Uinversity of Chinese Medicine, Beijing 100102, China.
Objective:
To prepare Maiyanning sustained-release patches and optimize the prescription.
Method:
The mono-factor design was used to screen the formulation of the sustained-release patches.
Result:
The optimal composition of the formulation was MD-607 as the pressure sensitive adhesive and azone as the penetration enhancer with the content of 5.0%. Drugs released from the pressure-sensitive adhesive patches in a constant speed, it confirmed that the drug was released by zero order equation from the patches.
Conclusion:
The prepared patches have an ideal release trait.
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