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Related Experiment Video

Updated: Jun 19, 2026

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
09:36

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study

Published on: March 8, 2024

[Alkaloids from Macleaya cordata].

Fengzhi Ye1, Feng Feng, Wenyuan Liu

  • 1Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|October 31, 2009
PubMed
Summary

This study isolated thirteen alkaloids from Macleaya cordata, including novel compounds for the Macleaya genus and M. cordata. These findings expand the known alkaloid diversity in this plant species.

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Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
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Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry

Published on: October 2, 2016

Area of Science:

  • Phytochemistry
  • Natural Product Chemistry
  • Medicinal Plant Research

Context:

  • Macleaya cordata is a plant species known for its rich alkaloid content.
  • Understanding the chemical constituents of medicinal plants is crucial for drug discovery and ethnopharmacology.
  • Previous research has identified various alkaloids, but a comprehensive analysis of M. cordata alkaloids is ongoing.

Purpose:

  • To isolate and identify the alkaloid constituents of Macleaya cordata.
  • To characterize novel alkaloids and those previously unrecorded in the Macleaya genus.
  • To contribute to the phytochemical database of Macleaya species.

Summary:

  • Thirteen alkaloids were successfully isolated and identified from Macleaya cordata using column chromatography and recrystallization.
  • The identified alkaloids include 6-methoxy-dihydrosanguinarine, norsanguinarine, and several others.
  • Notably, compounds 2, 3, and 5-9 were isolated from the Macleaya genus for the first time, and compound 1 was newly identified in M. cordata.

Impact:

  • This research expands the known phytochemical profile of Macleaya cordata.
  • The identification of new alkaloids provides potential leads for pharmacological studies and drug development.
  • The findings contribute to the chemotaxonomic understanding of the Macleaya genus.