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[Retrospective study of adverse events of Polygonum multiflorum and risk control]
Li Zhang1, Xiaohui Yang, Zhenxiao Sun
1Center for Drug Reevaluation, State Food and Drug Administration, Beijing 100045, China. yty0616@hotmail.com
Abstract:
To provide a reference for rational clinical medication and review the irrational use and factors relating the adverse events of Polygonum multiflorum. The literatures on P. multiflorum published between 1978 and 2008 were reviewed and the reports on clinical use were analyzed. A total of 26 literatures were retrieved. 38 cases of adverse drug event were reported, 10 cases of allergy, 24 cases of liver damage, and 4 cases presented with other adverse events. Irrational use is common in both self-medication and doctor prescription. It is one of the main factors of adverse events. Improving clinical rational use is the most important way to control its risk.
Insights
Polygonum multiflorum (P. multiflorum) use is linked to adverse events like liver damage and allergies. Improving rational clinical use is crucial to minimize risks associated with this herb.
Area of Science:
- Herbal Medicine
- Pharmacovigilance
- Clinical Pharmacology
Background:
- Polygonum multiflorum (P. multiflorum) is a traditional Chinese herb with widespread clinical use.
- Concerns exist regarding the safety profile and potential adverse events associated with P. multiflorum.
- A comprehensive review is needed to understand the patterns of its clinical use and associated risks.
Observation:
- A review of literature from 1978-2008 identified 26 relevant studies on P. multiflorum.
- 38 cases of adverse drug events were reported, including 10 allergies and 24 cases of liver damage.
- Other adverse events were noted in 4 cases, indicating a range of potential toxicities.
Findings:
- Irrational use of P. multiflorum was prevalent in both self-medication and physician-prescribed contexts.
- The identified adverse events, particularly liver damage, are significantly linked to irrational usage patterns.
- Lack of standardized dosing and preparation methods may contribute to unpredictable outcomes.
Implications:
- Enhancing rational clinical use of P. multiflorum is paramount for mitigating patient risk.
- Healthcare providers should exercise caution and provide clear guidance on P. multiflorum usage.
- Further research into the mechanisms of P. multiflorum toxicity and safer dosing strategies is warranted.
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