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Updated: Jun 19, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Undiagnosed squamous cell carcinoma of the forehead presenting as a Tolosa-Hunt syndrome
Jose Nieto Enriquez1, Ramón Medel Jiménez, Pere Huguet Redecilla
1Ophthalmology Service, Vall d'Hebrón University Hospital, Barcelona, Spain. jnieto@oculoplastica.net
Abstract:
Squamous cell carcinoma (SCC) is the second most common periocular skin cancer. We describe a case of invasive squamous cell carcinoma arising from actinic keratosis and causing orbital and intracranial invasion via perineural spread. Perineural invasion (PNI) is a known feature of SCC and very rarely basal cell carcinomas of the head and neck. A high degree of clinical suspicion is necessary to diagnose PNI. Varied clinical presentations have been described for this form of dissemination, including orbital apex syndrome as in our case. Prognosis is poor, with death resulting in over 50% of cases at 5 years.
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