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Updated: Jun 19, 2026

A Modified Co-Culture System for Understanding Granulosa-Theca Cell Interactions in the Bovine Ovary
Published on: September 19, 2025
Follicular development in pregnant cows after the administration of equine chorionic gonadotropin (eCG): a new
Annalisa Rizzo1, Massimo Spedicato, Giuseppe Minoia
1Department of Animal Production, Faculty of Veterinary Medicine, University of Bari, Bari, Italy.
Abstract:
The follicular development in the cow occurs in a wave-like pattern, and it takes place also during pregnancy. In the cow, Equine Chorionic Gonadotropin (eCG) is used for superovulation, but a decrease in total fertility has been reported, likely because of its immunogenic properties in species other than equine. In this regard, immune response has been implicated in follicular growth, ovulation, and placental development. So, aims of our study are to test the safety of eCG administered during pregnancy and characterize the ovarian activity, the quality of oocytes, the hormonal status, and interleukin levels in eCG-treated pregnant cows.
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