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Published on: May 31, 2017
A neurotrophic rationale for the therapy of neurodegenerative disorders
H Uri Saragovi1, Edith Hamel, Adriana Di Polo
1Pharmacology and Therapeutics, The Lady Davis Institute, Jewish General Hospital, University of Montréal, Montréal, Québec, Canada. Uri.Saragovi@mcgill.ca
Abstract:
The concept and rationale for neuroprotection are presented. Several examples of small molecule neurotrophic agents with favourable drug-like and pharmacological properties are shown. Compound efficacy in acute neurodegenerative models (optic nerve axotomy) and chronic neurodegenerative models (glaucoma, age-associated cognitive impairment, Alzheimer's Disease) are evaluated and discussed. Targeting neurotrophin receptors with ligands that activate survival pathways or inhibit death pathways is an alternative worth pursuing.
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Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
