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Related Concept Videos

Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

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Related Experiment Video

Updated: Jun 19, 2026

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
08:54

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Published on: February 14, 2018

Advances in paracoccidioidomycosis.

M Ameen1, C Talhari, S Talhari

  • 1St. John's Institute of Dermatology, Guy's and St Thomas' NHS Trust, London SE1 7EH, UK. mahreenameen@hotmail.com

Clinical and Experimental Dermatology
|October 31, 2009
PubMed
Summary

Paracoccidioidomycosis, a fungal infection prevalent in Latin America, is increasingly seen globally. Early dermatological diagnosis is key to managing this potentially fatal disease and preventing severe complications.

Related Experiment Videos

Last Updated: Jun 19, 2026

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
08:54

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Published on: February 14, 2018

Area of Science:

  • Mycology
  • Infectious Diseases
  • Dermatology

Background:

  • Paracoccidioidomycosis is the most common systemic fungal infection in Latin America.
  • Global relevance is increasing due to cases in travelers and immigrants from endemic areas.
  • The disease typically involves the lungs, lymph nodes, and chronic mucocutaneous lesions.

Purpose of the Study:

  • To review the clinical features and management of paracoccidioidomycosis.
  • To discuss recent advancements in diagnosis, prognosis, and treatment.
  • To highlight the role of dermatologists in early detection.

Main Methods:

  • Literature review of clinical features, diagnosis, and treatment.
  • Discussion of recent developments in molecular diagnostics.
  • Analysis of prognostic factors and therapeutic strategies.

Main Results:

  • Paracoccidioidomycosis presents with pulmonary, lymphatic, and mucocutaneous manifestations.
  • Skin lesions are common and aid in early diagnosis.
  • Untreated disease can lead to severe, fatal outcomes.

Conclusions:

  • Dermatological examination is crucial for early paracoccidioidomycosis diagnosis.
  • Advances in molecular diagnostics and therapies are improving patient outcomes.
  • Comprehensive management strategies are essential for this globally relevant mycosis.