Related Experiment Video
Updated: Jun 19, 2026
10:28
Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Chasing clot: thrombophilic states and the interventionalist
Karim Valji1, Michael Linenberger
1Department of Radiology, University of Washington, 1959 Northeast Pacific Street, Box 357115, Seattle, WA 98195, USA. kvalji@u.washington.edu
Journal of Vascular and Interventional Radiology : JVIR
|October 31, 2009
Summary
Thrombophilia, a risk factor for blood clots, involves genetic and acquired factors. Understanding these conditions is crucial for interventional radiologists managing patients with venous thromboembolism and arterial disease.
Area of Science:
- Medical Science
- Hematology
- Radiology
Background:
- Thrombophilia is a significant risk factor in idiopathic venous thromboembolism.
- It may also contribute to arterial thrombotic disease.
- Both inherited and acquired factors influence thrombotic risk.
Purpose of the Study:
- To review the disorders and prevalence of thrombophilia.
- To provide guidelines for managing thrombophilia cases.
- To highlight the importance of thrombophilia knowledge for interventional radiologists.
Main Methods:
- Literature review of thrombophilia disorders.
- Analysis of prevalence data for genetic and acquired thrombophilias.
- Synthesis of current understanding of thrombotic risk factors.
Main Results:
- Common genetic thrombophilias confer a modest risk.
- Less common thrombophilias are associated with a higher risk of pathological clot formation.
- Most thrombotic events result from combined inherited and acquired risks.
Conclusions:
- Understanding thrombophilia is essential for interventional radiologists.
- Management strategies should consider additive predisposing risks.
- This review offers guidance for handling patients with thrombophilia.
Related Concept Videos
01:29Venous Thrombosis III: Interprofessional Care
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
01:30Venous Thrombosis I: Introduction
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
01:27Peripheral Artery Disease III: Interprofessional Care
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
01:18Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...