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Related Concept Videos

Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...

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Updated: Jun 19, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Diabetes in Asia.

Ambady Ramachandran1, Ronald Ching Wan Ma, Chamukuttan Snehalatha

  • 1India Diabetes Research Foundation and Dr A Ramachandran's Diabetes Hospitals, Chennai, India. ramachandran@vsnl.com

Lancet (London, England)
|October 31, 2009
PubMed
Summary
This summary is machine-generated.

Type 2 diabetes is rising in Asian populations, affecting younger individuals and increasing cardiovascular disease risk. Urgent national strategies are needed for prevention and improved care.

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Last Updated: Jun 19, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Area of Science:

  • Endocrinology
  • Public Health
  • Epidemiology

Background:

  • Type 2 diabetes prevalence is rapidly increasing in native and migrant Asian populations.
  • Diabetes onset occurs at a younger age in Asian populations compared to white populations.
  • Younger age of onset and high cardiovascular risk factors in Asians significantly elevate lifetime cardiovascular disease risk.

Purpose of the Study:

  • To highlight the unique pathogenetic factors and thresholds for diabetes in Asian populations.
  • To underscore the substantial economic burden of diabetes.
  • To advocate for national strategies for public awareness, improved care standards, and primary prevention programs.

Main Methods:

  • This study is a review of existing literature and epidemiological data.
  • Analysis of prevalence trends and risk factors in Asian populations.
  • Assessment of the economic impact and healthcare system challenges.

Main Results:

  • Distinctive pathogenetic factors and lower thresholds for diabetes development are observed in Asian populations.
  • Increased morbidity and mortality from diabetes and its complications are prevalent in young Asian individuals.
  • The economic burden of diabetes is substantial at personal, societal, and national levels.

Conclusions:

  • Urgent national strategies are required to address the rising prevalence of type 2 diabetes in Asian populations.
  • Improved public awareness, standard of care, and primary prevention programs are crucial.
  • Targeted interventions considering the unique characteristics of diabetes in Asian populations are necessary.