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Published on: August 14, 2019
Bioproduction of resveratrol and stilbene derivatives by plant cells and microorganisms
David Donnez1, Philippe Jeandet, Christophe Clément
1Laboratoire de Stress, Défenses et Reproduction des Plantes, Unité de Recherche Vigne et Vins de Champagne-Stress et Environnement, EA 2069, UFR Sciences Exactes et Naturelles, Université de Reims Champagne-Ardenne, BP 1039, 51687 Reims Cedex 02, France.
Abstract:
Trans-resveratrol is a phenolic plant compound that has been recognized for its benefits on human health. Currently, increasing demand for trans-resveratrol for nutraceutical, cosmetic, and putatively pharmaceutic uses makes its production from sustainable sourcing a necessity. In this context, the use of biotechnology through recombinant microorganisms and plant cell suspensions is particularly promising because it represents a reliable alternative method of trans-resveratrol production under controlled conditions. Tailoring yeast or bacteria with genes that encode enzymes of the trans-resveratrol pathway and further elicitation of plant-cell metabolism might represent powerful strategies for increased trans-resveratrol bioproduction. This review aims at describing and comparing these different available methods, with a focus on their respective advantages, limits and perspectives as a basis for scale-up in large culture volumes.
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