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Use of 5-hydroxy-4H-benzo[1,4]oxazin-3-ones as beta2-adrenoceptor agonists

Christoph Hoenke1, Thierry Bouyssou, Christofer S Tautermann

  • 1Department of Chemical Research, Boehringer Ingelheim Pharma GmbH & Co KG, 88397 Biberach, Germany.

Bioorganic & Medicinal Chemistry Letters
|October 31, 2009
PubMed

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Drugs that mimic the action of endogenous catecholamines like noradrenaline and adrenaline are called adrenergic agonists or sympathomimetics. Based on their mechanism of action, sympathomimetics can be classified as direct-, indirect-, or mixed-acting sympathomimetics. Direct-acting adrenergic agonists activate adrenoceptors without affecting presynaptic neurons, making them independent of neuronal catecholamine-depleting agents like reserpine and guanethidine.
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Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
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