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Prevalence of dyslipidemia in adults with cystic fibrosis

Bronwen Rhodes1, Edward F Nash, Elizabeth Tullis

  • 1Toronto Adult Cystic Fibrosis Program, St. Michael's Hospital, 30 Bond Street, 6th Floor, Toronto, ON, Canada M5B 1W8.

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
|October 31, 2009
PubMed

Insights

Dyslipidemia is common in cystic fibrosis (CF) patients, affecting males and those with pancreatic sufficiency. Monitoring fasting lipids is crucial, especially for older patients with higher BMI, as complications may rise with increased survival.

Area of Science:

  • Cardiovascular Health
  • Metabolic Disorders
  • Cystic Fibrosis Research

Background:

  • High-fat diets are recommended for cystic fibrosis (CF) patients.
  • Lipid profiles in CF patients, including those with CF-related diabetes (CFRD), are understudied.

Purpose of the Study:

  • To investigate lipid profiles in adult CF patients.
  • To compare lipid profiles between CF patients with and without diabetes.

Main Methods:

  • Retrospective review of adult CF patients.
  • Data collected between January 2005 and December 2007.
  • Analysis of lipid profiles, including HDL cholesterol, total cholesterol, and triglycerides.

Main Results:

  • Dyslipidemia is prevalent in CF patients (334 included).
  • Males had significantly lower HDL cholesterol.
  • Pancreatic sufficient patients were more likely to have higher total cholesterol.
  • Lipid profiles did not differ significantly between diabetic and non-diabetic CF patients.
  • Total cholesterol and triglycerides increased with age and BMI.

Conclusions:

  • Dyslipidemia is common in CF patients, irrespective of diabetes status.
  • Fasting lipid monitoring is recommended for CF patients, particularly those with pancreatic sufficiency, older age, and high BMI.
  • Increased survival in CF may lead to a higher prevalence of dyslipidemia and related complications.
Abstract

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