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Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
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PRP as a New Approach to Prevent Infection: Preparation and In vitro Antimicrobial Properties of PRP
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Platelet-rich plasma: from basic science to clinical applications.

Timothy E Foster1, Brian L Puskas, Bert R Mandelbaum

  • 1Boston University School of Medicine, Boston, MA 02118, USA. mdsportsmed@aol.com

The American Journal of Sports Medicine
|October 31, 2009
PubMed
Summary

Platelet-rich plasma (PRP) aids healing for sports injuries by using growth factors. This review covers PRP

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Area of Science:

  • Orthopaedic surgery
  • Sports medicine
  • Regenerative medicine

Background:

  • Platelet-rich plasma (PRP) has been used in surgery for 20 years.
  • Recent interest focuses on PRP for sports injury treatment.
  • PRP contains growth factors and proteins crucial for tissue healing.

Purpose of the Study:

  • To examine the basic science of PRP.
  • To describe current clinical applications in sports medicine.
  • To review human studies on PRP in orthopaedics and sports medicine.

Main Methods:

  • Literature review of published human studies.
  • Evaluation of studies in orthopaedic surgery and sports medicine journals.
  • Analysis of PRP use in amateur and professional sports.

Main Results:

  • PRP contains bioactive proteins and growth factors.
  • PRP influences tendon, ligament, muscle, and bone healing.
  • Current clinical applications in sports medicine are reviewed.

Conclusions:

  • PRP shows promise for treating sports-related injuries.
  • Further review of human studies is needed.
  • Regulation by antidoping agencies is a consideration.