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Muscle-derived cell injection to treat anal incontinence due to obstetric trauma: pilot study with 1 year follow-up
A Frudinger1, D Kölle, W Schwaiger
1Obstetrics & Gynaecology, Medical University of Graz, Austria.
Objective:
To treat anal incontinence due to obstetric external anal sphincter disruption via injection of autologous myoblast cells.
Design:
Observational pilot study.
Setting:
University hospital and district hospital
Patients:
10 women suffering from anal incontinence due to obstetric anal sphincter injury, refractory to conventional non-surgical therapy.
Interventions:
Autologous myoblasts were cultured from a pectoralis muscle biopsy, harvested, and injected into the external anal sphincter defect using direct ultrasound guidance.
Main Outcome Measures:
Wexner incontinence score, anal squeeze pressures, and quality of life 12 months after injection. Safety and technical feasibility.
Results:
The procedure was well tolerated and no adverse events were observed. At 12 months the Wexner incontince score had decreased by a mean of 13.7 units (95% CI, -16.3 to -11.2), anal squeeze pressures were unchanged, and overall quality of life scores improved by a median of 30 points (95% CI, 25 to 42). Anal squeeze pressures did rise significantly at 1 month and 6 months post-injection (p = 0.03).
Conclusions:
Injection of autologous myoblasts is safe, well tolerated, and significantly improves symptoms of anal incontinence due to obstetric anal sphincter trauma.