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Predictive Immune Modeling of Solid Tumors

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

IPD--the Immuno Polymorphism Database.

James Robinson¹, Kavita Mistry, Hamish McWilliam

¹Anthony Nolan Research Institute, Royal Free Hospital, Hampstead, London NW3 2QG, UK.

Nucleic Acids Research

|October 31, 2009

Summary

This summary is machine-generated.

The Immuno Polymorphism Database (IPD) provides curated genetic data for immune system research. It includes specialized databases for Killer-cell Immunoglobulin-like Receptors, Major Histocompatibility Complex, human platelet antigens, and tumor cell lines.

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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Area of Science:

Immunoinformatics
Genomics
Bioinformatics

Background:

The study of polymorphic genes in the immune system is crucial for understanding immune responses and diseases.
Specialist groups and nomenclature committees play a vital role in curating and validating genetic data.
Accessible, centralized databases are essential for researchers in immunology and genetics.

Purpose of the Study:

To present the Immuno Polymorphism Database (IPD) as a comprehensive resource for polymorphic immune system genes.
To detail the structure and content of the IPD, including its specialized sub-databases.
To highlight the collaborative approach in data curation and the online accessibility of the IPD.

Main Methods:

Data curation by specialist groups and nomenclature committees.
Integration of data into a set of related, centralized databases.
Online publication and accessibility via website and FTP directory.

Main Results:

The IPD currently comprises four distinct databases: IPD-KIR, IPD-MHC, IPD-human platelet antigens, and IPD-ESTDAB.
Each database focuses on specific polymorphic gene families or cell types relevant to the immune system.
The IPD offers a unified platform for accessing diverse immunological genetic data.

Conclusions:

The IPD serves as a valuable, integrated resource for researchers studying immune system genetics.
The collaborative model ensures high-quality, curated data for the scientific community.
Online accessibility facilitates widespread use and advancement in immunological research.