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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...

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Related Experiment Video

Updated: Jun 19, 2026

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

Obesity and lung inflammation.

Peter Mancuso1

  • 1Department of Environmental Health Sciences, School of Public Health, SPH IA Tower, 109 S. Observatory St., Ann Arbor, MI 48109-2029, USA. pmancuso@umich.edu

Journal of Applied Physiology (Bethesda, Md. : 1985)
|October 31, 2009
PubMed
Summary

Obesity significantly impacts lung health by promoting inflammation and increasing susceptibility to respiratory diseases. Understanding these mechanisms is key to developing new treatments for lung conditions.

Area of Science:

  • Pulmonary Medicine
  • Immunology
  • Metabolic Disease

Background:

  • Rising global obesity rates increase risks for cardiovascular disease and type 2 diabetes.
  • Obesity's role in pulmonary disease pathogenesis, involving adipose-derived inflammatory mediators, is increasingly recognized.
  • Adipose tissue influences lung immune responses and susceptibility to respiratory issues.

Purpose of the Study:

  • To explore the mechanisms linking obesity to pulmonary inflammation.
  • To investigate how adipose tissue mediators affect lung immunity.
  • To identify potential therapeutic targets for obesity-related lung diseases.

Main Methods:

  • Review of animal models demonstrating inflammatory responses in the lung due to obesity.
  • Analysis of adipocytokines (leptin, adiponectin), cytokines, and acute-phase proteins.

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Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
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Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

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Last Updated: Jun 19, 2026

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
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Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
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Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

  • Examination of obesity's impact on pulmonary infection susceptibility and environmental exposures.

    • Main Results:

    • Obesity contributes to systemic low-grade inflammation via adipose tissue-derived mediators.
    • Lung inflammatory responses can modulate adipose tissue mediator production.
    • Increased adipose tissue mass exacerbates airway obstruction and susceptibility to infections.

    Conclusions:

    • Obesity is a significant factor in pulmonary disease development and progression.
    • Adipose tissue mediators play a crucial role in obesity-induced lung inflammation.
    • Further understanding may lead to novel therapeutic strategies for lung diseases in obese individuals.