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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
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Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...

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Related Experiment Video

Updated: Jun 19, 2026

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment
08:49

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment

Published on: August 2, 2024

Delayed graft function and the risk for death with a functioning graft.

Shruti N Tapiawala1, Kathryn J Tinckam, Carl J Cardella

  • 1Division of Nephrology, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

Journal of the American Society of Nephrology : JASN
|October 31, 2009
PubMed
Summary
This summary is machine-generated.

Delayed graft function (DGF) after kidney transplant increases the risk of death with a functioning graft. Further research is needed to understand the mechanisms behind this association.

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Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Biostatistics

Background:

  • Delayed graft function (DGF) is a known risk factor for kidney transplant graft failure.
  • The association between DGF and death with a functioning graft (DWGF) has not been previously established.

Purpose of the Study:

  • To investigate the relationship between DGF and the risk of DWGF in adult deceased-donor kidney transplant recipients.
  • To explore potential modifying factors and causes of death associated with DGF and DWGF.

Main Methods:

  • Utilized the US Renal Data System to identify a cohort of first, adult, deceased-donor kidney transplant recipients (1998-2004).
  • Analyzed data from 50,246 recipients, with 11,542 experiencing DGF (requiring dialysis within the first week post-transplant).
  • Employed survival analysis models to compare risks between DGF and non-DGF groups, adjusting for relevant covariates.

Main Results:

  • Patients with DGF had a significantly higher likelihood of DWGF compared to those without DGF (adjusted hazard ratio 1.53).
  • The risk of DWGF was slightly elevated in women with DGF compared to men.
  • Acute rejection within the first year post-transplant partially explained the DGF-DWGF association; cardiovascular and infectious deaths were more prevalent in the DGF group.

Conclusions:

  • Delayed graft function is independently associated with an increased risk of death with a functioning graft.
  • The underlying mechanisms contributing to the negative impact of DGF on transplant outcomes warrant further investigation.
  • Understanding these mechanisms may lead to improved management strategies for kidney transplant recipients experiencing DGF.