Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The diploid reference genome of a human embryonic stem cell line.

bioRxiv : the preprint server for biology·2026

Same author

Germline-targeted baboon apolipoprotein L-1 protects mice against African trypanosomes.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites.

Cell·2026

Same author

Stabilized real-time Brillouin microscopy reveals fractal organization of protein condensates in living cells.

Nature communications·2026

Same author

Crosstalk between tissue mechanics and BMP4 signaling regulates symmetry breaking in human gastrula models.

Cell stem cell·2025

Same author

Heat Shock Proteins: Important Helpers for the Development, Maintenance and Regeneration of Skeletal Muscles.

Muscles (Basel, Switzerland)·2025

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

In ovo Expression of MicroRNA in Ventral Chick Midbrain

In ovo Expression of MicroRNA in Ventral Chick Midbrain

Published on: September 16, 2013

MicroRNAs in early vertebrate development.

Alessandro Rosa¹, Ali H Brivanlou

¹Laboratory of Molecular Vertebrate Embryology, The Rockefeller University, New York, NY, USA.

Cell Cycle (Georgetown, Tex.)

|October 31, 2009

Summary

This summary is machine-generated.

MicroRNAs are crucial for embryonic development, regulating key processes like cell fate and body axis formation. This review explores their role in vertebrate and human embryonic stem cell development.

More Related Videos

Preparation of Small RNA Libraries for Sequencing from Early Mouse Embryos

Preparation of Small RNA Libraries for Sequencing from Early Mouse Embryos

Published on: October 9, 2020

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

Published on: February 16, 2017

Related Experiment Videos

Last Updated: Jun 19, 2026

In ovo Expression of MicroRNA in Ventral Chick Midbrain

In ovo Expression of MicroRNA in Ventral Chick Midbrain

Published on: September 16, 2013

Preparation of Small RNA Libraries for Sequencing from Early Mouse Embryos

Preparation of Small RNA Libraries for Sequencing from Early Mouse Embryos

Published on: October 9, 2020

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

Published on: February 16, 2017

Area of Science:

Developmental Biology
Molecular Biology
Genetics

Background:

Embryonic development requires precise gene expression hierarchies for proper organ and cell formation.
MicroRNAs (miRNAs) are key regulators of post-transcriptional gene expression in animals and plants.
Recent research highlights miRNAs as critical players in embryogenesis.

Purpose of the Study:

To review the significant roles of microRNAs in early vertebrate embryonic development.
To discuss the function of microRNAs in human embryonic stem cells as a model for human development.

Main Methods:

Literature review of studies on microRNA function in vertebrate embryogenesis.
Analysis of research on microRNAs in human embryonic stem cell differentiation.

Main Results:

MicroRNAs regulate fundamental developmental processes including organizer induction, cell fate determination, and body axis formation.
Studies in vertebrate model systems and human embryonic stem cells demonstrate conserved and specific miRNA functions.

Conclusions:

MicroRNAs are essential regulators of early development across diverse species.
Understanding miRNA roles in human embryonic stem cells provides insights into human developmental processes.