A pre-emptive strike against malaria's stealthy hepatic forms
Related Experiment Video
Updated: Jun 19, 2026

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
Published on: July 11, 2025
Dominique Mazier1, Laurent Rénia, Georges Snounou
1Dominique Mazier and Georges Snounou are at the Institut National de la Santé et de la Recherche Médicale U945, F-75013 Paris, France. dominique.mazier@upmc.fr
Abstract:
Almost all the drugs that are widely used today against Plasmodium spp., the causative agent of malaria, target the asexual blood stages of the parasite. Widespread drug resistance severely restricts our ability to control malaria and makes it necessary to seek novel antimalarial compounds. Here, we advocate the development of true causal chemoprophylactic drugs that will fully inhibit the obligate short-lived hepatic forms that precede blood infections. Such drugs will prevent pathology and interrupt transmission, and could therefore have an important role in the control of malaria and its eventual eradication.
More Related Videos
05:28Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors
Published on: May 12, 2022
09:13Understanding the Development of Compensatory Pathways in a Mutant Malaria Parasite Harbouring Hypomorphic Allele of Plant-Like Kinases
Published on: November 22, 2024
Related Concept Videos
Malaria
Anthelminthic Agents
Antiprotozoal Agents
Symbiosis
Toxoplasmosis