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Updated: Jun 19, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
09:04

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Published on: March 15, 2016

Axitinib--a selective inhibitor of the vascular endothelial growth factor (VEGF) receptor

Ronan J Kelly1, Olivier Rixe

  • 1National Cancer Institute, Medical Oncology Branch, Center for Cancer Research, Bethesda, MD 20892, USA.

Targeted Oncology
|October 31, 2009
PubMed

Insights

Axitinib, a targeted therapy, shows promise in treating various solid tumors by inhibiting vascular endothelial growth factor (VEGF) receptors. Further research is ongoing to optimize its use in specific cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Advances in understanding tumor molecular biology have enabled targeted therapies.
  • Axitinib targets vascular endothelial growth factor (VEGF) receptor tyrosine kinases 1, 2, and 3.

Purpose of the Study:

  • To review preclinical and clinical data for axitinib.
  • To explore axitinib's efficacy across various solid tumors.
  • To compare axitinib with other VEGF receptor inhibitors.

Main Methods:

  • Review of preclinical studies.
  • Analysis of Phase II clinical trial data in diverse tumor types (melanoma, renal, pancreatic, thyroid, breast, lung, colorectal).
  • Exploration of potential predictive biomarkers (blood pressure, erythropoietin levels).

Main Results:

  • Axitinib demonstrates activity in a range of solid tumors.
  • Potential predictive markers for VEGF/VEGFR pathway inhibition were identified.

Conclusions:

  • Axitinib is a potent VEGF receptor inhibitor with broad potential in solid tumors.
  • Ongoing Phase III trials will define optimal use in pancreatic and metastatic renal cell carcinoma.

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