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Central leptin versus ghrelin: effects on bone marrow adiposity and gene expression
Suresh Ambati1, Qiang Li, Srujana Rayalam
1Department of Animal & Dairy Science, University of Georgia, 444 Animal Science Complex, Athens, GA 30602-2771, USA.
Endocrine
|October 31, 2009
Summary
Leptin reduces body weight and fat, while ghrelin increases body weight in rats. Both hormones impact gene expression in adipose tissue and bone marrow, with leptin decreasing adiposity.
Area of Science:
- Endocrinology
- Metabolism
- Molecular Biology
Background:
- Ghrelin and leptin are key hormones regulating energy homeostasis.
- Their central effects on adiposity and gene expression in both adipose tissue and bone marrow require further elucidation.
Purpose of the Study:
- To compare the central effects of ghrelin and leptin on body weight, food intake, adiposity, and gene expression in adipose tissue and bone marrow.
Main Methods:
- Male Sprague-Dawley rats received intracerebroventricular (ICV) injections of control, ghrelin, or leptin for 5 days.
- Body weight, food intake, and gene expression in adipose tissue and bone marrow were assessed using RT-PCR.
Main Results:
- Leptin reduced food intake and body weight, while ghrelin increased body weight.
- Leptin decreased fat pad weights and altered gene expression related to lipolysis and adipogenesis in adipose tissue and bone marrow.
- Ghrelin increased fat pad weights and specific adipogenic markers in adipose tissue.
Conclusions:
- Leptin centrally reduces adiposity in both adipose tissue and bone marrow, evidenced by decreased adipocyte size/number and coordinated gene expression changes.
- Ghrelin's central administration increases body weight and affects adipogenic gene expression in adipose tissue, with no significant impact on bone marrow adiposity.
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