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Assessment of Endothelial Cell Migration After Exposure to Toxic Chemicals
Published on: July 10, 2015
Long-term complications of sulphur mustard poisoning in intoxicated Iranian veterans
Soha Namazi1, Hosein Niknahad, Hasan Razmkhah
1Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Science, Shiraz, Iran. sohanamazi@yahoo.com
Introduction:
Sulphur mustard (SM) is an alkylating chemical warfare agent that was widely used during the Iran-Iraq conflict(1980-1988). Delayed complications of SM in different organs were evaluated in this study.
Methods:
This cross-sectional study was performed from March 2005 to June 2006. The Veterans Foundation provided us with the files of all chemical warfare-poisoned patients in the province of Fars, Iran. Clinical manifestations, laboratory data, and demographic characteristics of the patients were recorded from their files and a face-to-face interviews. Data analysis was performed by student t test statistical method.
Results:
A total of 134 patients were enrolled in the study. The age range of the patients was 32-45 (37.2+/-9) years. SM poisoning was confirmed 19.5+/-1.6 (17-22) years after initial exposure. The duration of exposure in patients was 13.35+/-8.7 (1.5-48) hours. The most common complication was found in the lungs (100%), skin (82.84%), and eyes (77.61%). The most frequent medications used for the treatment of these complications were: bronchodilators, drugs used for dermatological problems, and drugs used for ocular complications. Analytical study showed no association between the age of exposed patients and the severity of toxic complications (p>.05), but there was a significant association between the duration of exposure and the number of complications (p<.05).
Conclusion:
Results of this study indicate that respiratory complications generally increase over time. Therefore, follow-up of veterans exposed to SM is recommended. This may lead to early diagnosis of SM complications and help prevent the late manifestations of this toxicity.
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