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Assessing disease progression with MRI in atypical parkinsonian disorders

Martin Köllensperger1, Gregor K Wenning

  • 1Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.

Movement Disorders : Official Journal of the Movement Disorder Society
|October 31, 2009
PubMed

Insights

Novel magnetic resonance (MR) techniques aid in early Parkinsonism diagnosis and tracking disease progression. This review covers advancements for multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and dementia with Lewy bodies (DLB).

Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Parkinsonism encompasses a range of neurological disorders.
  • Accurate early differential diagnosis is crucial for effective management.
  • Traditional diagnostic methods have limitations in differentiating subtypes.

Purpose of the Study:

  • To review novel magnetic resonance (MR) techniques for Parkinsonism.
  • To highlight MR's role in early differential diagnosis of atypical parkinsonian disorders.
  • To discuss MR surrogate markers for disease progression monitoring.

Main Methods:

  • Review of recent advancements in MR imaging techniques.
  • Focus on applications in multiple system atrophy (MSA).
  • Focus on applications in progressive supranuclear palsy (PSP).
  • Focus on applications in dementia with Lewy bodies (DLB).

Main Results:

  • Emerging MR techniques offer improved diagnostic accuracy.
  • Specific MR findings can differentiate between MSA, PSP, and DLB.
  • MR-based markers show potential for tracking disease progression.

Conclusions:

  • Novel MR techniques are transforming the diagnostic landscape of Parkinsonism.
  • These advancements facilitate earlier and more precise differential diagnoses.
  • MR imaging is becoming indispensable for monitoring disease trajectory.

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