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A Catheter-Related Candida albicans Infection Model in Mouse
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Candidaemia in patients with an inserted medical device

Roberto Cauda1

  • 1Institute of Clinical Infectious Diseases, Catholic University, Rome, Italy. rcauda@rm.unicatt.it

Drugs
|November 3, 2009
PubMed

Insights

Candida species increasingly cause medical device infections, particularly bloodstream and urinary tract infections. Antifungal treatments like echinocandins show promise for future therapies, especially for device-associated candidal infections.

Area of Science:

  • Medical microbiology
  • Infectious diseases
  • Biomedical engineering

Background:

  • Medical devices are recognized as significant sources of healthcare-associated infections.
  • Candida species are increasingly implicated in device-related infections, affecting various sites like the bloodstream and urinary tract.

Purpose of the Study:

  • To highlight the growing problem of Candida species in medical device infections.
  • To review current treatment strategies and explore future therapeutic options.

Main Methods:

  • Literature review on device-related candidal infections.
  • Analysis of current antifungal treatment guidelines.
  • Evaluation of emerging therapies, including echinocandins.

Main Results:

  • Candida colonization affects diverse medical devices such as catheters, cardiac devices, and prostheses.
  • Device-related candidal infections necessitate antifungal treatment and often device removal.
  • Echinocandins demonstrate efficacy against Candida biofilms.

Conclusions:

  • Medical device-associated candidal infections pose a significant clinical challenge.
  • Current treatments involve amphotericin B, azoles, and echinocandins.
  • Echinocandins may offer future advantages in lock therapy for device-associated candidal infections due to their anti-biofilm activity.

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