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A case-control study on risk factors of osteoporosisin patients with Crohn's disease
Homayoun Vahedi1, Shabnam Momtahen, Golrokh Olfati
1Digestive Disease Research Center, Shariati Hospital, Medical Sciences/ University of Tehran, Iran. vahedi@ams.ac.ir
Background:
Osteoporosis has been frequently reported in patients with inflammatory bowel diseases, especially Crohn's disease.
Methods:
All consecutive Crohn's disease patients who attended the GI Clinics at Shariati Hospital, Tehran, Iran, from 2004 to 2007 were evaluated. A BMD-DEXA assessment was performed for all patients. Among those patients diagnosed with osteoporosis (T score
Results:
In this study, a multivariable modeling technique revealed a higher osteoporosis risk in those who had a lower body mass index, previous fractures and longer disease duration. A cumulative corticosteroid dose of 10 - 35 g provided the highest osteoporosis risk. Age, sex, bowel resection, site of disease, smoking and consumption of calcium and vitamin D did not show any relationship with osteoporosis.
Conclusion:
The highest osteoporosis risk was seen in patients with a cumulative 10 - 35 g corticosteroid dose and could be due to both steroid inefficiency in reducing Crohn's disease inflammation as well as the cumulative drug dose and it's adverse effect on patients.
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