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Related Concept Videos

Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

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Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
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Published on: August 14, 2019

Evaluating the relationship between memory functioning and cingulum bundles in acute mild traumatic brain injury

Trevor C Wu1, Elisabeth A Wilde, Erin D Bigler

  • 1Department of Psychology, Brigham Young University, Provo, Utah, USA.

Journal of Neurotrauma
|November 3, 2009
PubMed
Summary

Mild traumatic brain injury (mTBI) can affect memory. Diffusion tensor imaging (DTI) revealed cingulum bundle damage in adolescents with mTBI, correlating with memory deficits.

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Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Published on: July 28, 2013

Area of Science:

  • Neuroscience
  • Radiology
  • Cognitive Psychology

Background:

  • Mild traumatic brain injury (mTBI) frequently results in cognitive deficits, particularly memory impairment.
  • The cingulate, due to its anatomical location and shape, is particularly susceptible to injury following mTBI.
  • Diffusion tensor imaging (DTI) is a sensitive tool for detecting microstructural changes post-mTBI.

Purpose of the Study:

  • To investigate the integrity of cingulum bundles using DTI in adolescents with mTBI.
  • To explore the relationship between cingulum bundle integrity and memory functioning in this population.

Main Methods:

  • Diffusion tensor imaging (DTI) was used to assess cingulum bundle microstructure in 12 adolescents with mTBI and 11 healthy controls.
  • Participants underwent neuroimaging an average of 2.92 days post-injury.
  • Episodic verbal learning and memory were evaluated using the Verbal Selective Reminding Test (VSRT).

Main Results:

  • Adolescents with mTBI exhibited significantly lower bilateral apparent diffusion coefficient (ADC) values compared to controls.
  • A moderate effect size was observed for fractional anisotropy (FA) differences between groups.
  • In the mTBI group, left cingulum bundle FA correlated with delayed recall, and ADC correlated with immediate recall.

Conclusions:

  • Cingulate bundle microstructural alterations, detectable by DTI, are present in the early phase post-mTBI.
  • These DTI-derived metrics show preliminary correlations with specific memory functions in adolescents with mTBI.
  • Cingulate injury appears to contribute to early cognitive sequelae following mild traumatic brain injury.