Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction. It is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endothelial cell migration on surfaces modified with immobilized adhesive peptides.

Biomaterials·2000
Same author

Migration of lymphocytes on fibronectin-coated surfaces: temporal evolution of migratory parameters.

Biomaterials·1999
Same author

Bioenergetics of rat prostate cancer cell migration.

The Prostate·1998
Same author

A model for the kinetics of homotypic cellular aggregation under static conditions.

Biophysical journal·1997
Same author

A quantitative assay for intercellular aggregation.

Annals of biomedical engineering·1997
Same author

Induction of homotypic lymphocyte aggregation: evidence for a novel activation state of the beta1 integrin.

Journal of leukocyte biology·1996

Related Experiment Video

Updated: Jun 19, 2026

Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection
11:00

Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection

Published on: June 23, 2023

Quantification and regulation of cell migration.

K Zygourakis1

  • 1Department of Chemical Engineering and Institute of Biosciences and Bioengineering, Rice University, Houston, Texas 77251-1892.

Tissue Engineering
|November 3, 2009
PubMed
Summary

Cell migration, crucial for development and disease, is modulated by growth factors and adhesion molecules. Understanding cell motility impacts tissue formation rates and biomedical applications.

Area of Science:

  • Cell Biology
  • Biomedical Engineering
  • Physiology

Background:

  • Cell migration is fundamental to numerous physiological and pathological processes.
  • These processes include embryonic development, immune response, wound healing, angiogenesis, and cancer metastasis.
  • Cell migration is also vital for tissue engineering applications like tissue reconstitution and implant colonization.

Purpose of the Study:

  • To review the role of growth factors and substrate-adhesion molecules in cell motility.
  • To highlight the significance of cell motility in tissue formation rates.
  • To discuss methods for analyzing cell migration and proliferation.

Main Methods:

  • Summarizing recent experimental studies on cell migration.
  • Reviewing theoretical studies on cell motility.

More Related Videos

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy
07:27

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy

Published on: May 13, 2012

Analysis of Cell Migration within a Three-dimensional Collagen Matrix
08:02

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Published on: October 5, 2014

Related Experiment Videos

Last Updated: Jun 19, 2026

Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection
11:00

Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection

Published on: June 23, 2023

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy
07:27

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy

Published on: May 13, 2012

Analysis of Cell Migration within a Three-dimensional Collagen Matrix
08:02

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Published on: October 5, 2014

  • Discussing cell motility assays and theoretical models.

    • Main Results:

    • Growth factors and substrate-adhesion molecules significantly modulate cell motility.
    • Cell motility is a key determinant of tissue formation rates.
    • Various assays and models are available for analyzing cell migration and proliferation.

    Conclusions:

    • Cell migration is a critical biological process with broad implications.
    • Modulation of cell motility by specific factors influences tissue development and disease progression.
    • Further research utilizing cell motility assays and theoretical models can advance tissue engineering and disease treatment.