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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

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Updated: Jun 19, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Allergy prevention.

Cathleen Muche-Borowski1, Matthias Kopp, Imke Reese

  • 1Guideline of the German Society for Allergology and Clinical Immunology (DGAKI) in cooperation with the Society of German Allergologists (ADA), the German Society for Pediatric and Adolescent Medicine (DGKJ), the German Society of Dermatology (DDG) and the German Society of Pediatric Allergology (GPA).

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|November 3, 2009
PubMed
Summary
This summary is machine-generated.

Updated allergy prevention guidelines emphasize avoiding environmental tobacco smoke, mold, and pets for at-risk children. New recommendations include fish consumption and reducing air pollutant exposure to prevent allergies.

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Last Updated: Jun 19, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Area of Science:

  • Allergy and immunology
  • Public health
  • Evidence-based medicine

Background:

  • Rising allergy prevalence in industrialized nations necessitates updated primary prevention strategies.
  • Previous guidelines from 2004 required revision based on new scientific evidence.
  • A systematic literature search was conducted to update recommendations.

Observation:

  • Evidence from February 2003 to May 2008 was systematically reviewed.
  • 217 studies, including reviews, meta-analyses, and trials, were critically appraised.
  • Recommendations were revised through a formal consensus process.

Findings:

  • Key unchanged recommendations include avoiding environmental tobacco smoke, mold, and furry pets for at-risk children, and breastfeeding.
  • The recommendation for reducing house dust mite exposure was omitted; delayed food introduction impact was reduced.
  • New recommendations focus on fish consumption, avoiding overweight, and reducing exposure to air pollutants.

Implications:

  • Provides evidence-based, up-to-date recommendations for primary allergy prevention.
  • Confirms existing strategies, revises others, and introduces new preventive measures.
  • Aims to mitigate the increasing burden of allergies in industrialized countries.