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Related Experiment Video

Updated: Jun 19, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

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Published on: April 14, 2014

Optic neuritis: a review.

P N Shams1, G T Plant

  • 1The National Hospital for Neurology and Neurosurgery, London, UK. gordon@plant.globalnet.co.uk

International MS Journal
|November 3, 2009
PubMed
Summary
This summary is machine-generated.

Acute demyelinating optic neuritis (ON) often presents before multiple sclerosis (MS). While corticosteroids speed recovery, brain lesions strongly predict MS development, necessitating early treatment consideration.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Immunology

Background:

  • Acute demyelinating optic neuritis (ON) is a common initial symptom of multiple sclerosis (MS), affecting vision.
  • The Optic Neuritis Treatment Trial (ONTT) provides critical data on ON's natural history and treatment outcomes.

Purpose of the Study:

  • To analyze the natural history of optic neuritis.
  • To evaluate the efficacy of high-dose corticosteroids in treating optic neuritis.
  • To identify predictors for the development of multiple sclerosis after optic neuritis.

Main Methods:

  • Analysis of data from the Optic Neuritis Treatment Trial (ONTT).
  • Assessment of visual recovery over time.
  • Correlation of brain MRI findings (white matter lesions) with MS development.

Main Results:

  • Visual function typically recovers spontaneously within 12 months, with 93% achieving at least 20/40 acuity.
  • High-dose corticosteroids accelerate visual recovery but do not improve long-term visual outcomes.
  • The 10-year recurrence risk for ON is 35%.
  • Brain white matter lesions are strong predictors of MS; 15-year MS risk is 25% without lesions and 75% with lesions.

Conclusions:

  • Early axonal damage in ON suggests considering disease-modifying drugs for high-risk patients.
  • Prophylactic treatment may prevent permanent neurological impairment in individuals likely to develop MS.
  • ONTT findings underscore the importance of MRI in predicting MS conversion and guiding prophylactic treatment decisions.