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Updated: Jun 19, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Acute amnesia in MS revisited
1Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, L9 7LJ, UK. a.larner@thewaltoncentre.nhs.uk
Abstract:
Although cognitive problems in multiple sclerosis (MS) are increasingly recognized, acute amnesia in MS appears to be very rare. Hence, this presentation should always prompt consideration of other diagnoses. Nonetheless, as illustrated by the following case report, acute onset of demyelinating disease with the clinical phenotype of amnesia may on occasion be the presenting feature of MS.
Insights
Acute amnesia is a rare symptom of multiple sclerosis (MS). This case highlights that demyelinating disease can present as amnesia, prompting consideration of MS in such rare instances.
Area of Science:
- Neurology
- Neuroimmunology
- Cognitive Neuroscience
Background:
- Cognitive impairments are common in multiple sclerosis (MS).
- Acute amnesia is an exceptionally rare manifestation of MS.
- Differentiating MS from other causes of amnesia is crucial for timely diagnosis and treatment.
Observation:
- A case report details a patient presenting with acute-onset amnesia.
- The patient's symptoms mimicked other neurological conditions.
- Diagnostic workup revealed an underlying demyelinating disease.
Findings:
- The patient was diagnosed with multiple sclerosis.
- The amnesic presentation was attributed to acute demyelination.
- This case underscores the atypical presentations of MS.
Implications:
- Clinicians should consider multiple sclerosis in patients with acute amnesia, even if rare.
- Early recognition of demyelinating disease presenting as amnesia can improve patient outcomes.
- This case expands the spectrum of clinical phenotypes associated with MS.
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