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Related Concept Videos

Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Hormones of the Adrenal Glands01:31

Hormones of the Adrenal Glands

Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and corticosterone...
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Related Experiment Video

Updated: Jun 19, 2026

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

[Recent data in adrenocortical tumorigenesis].

A Crand1, F Borson-Chazot, T Brue

  • 1Fédération d'endocrinologie du pôle Est, Hospices Civils de Lyon, 59, Boulevard Pinel, 69677 Bron. alexandra.crand@chu-lyon.fr

Annales D'Endocrinologie
|November 3, 2009
PubMed
Summary
This summary is machine-generated.

Adrenocortical carcinomas are aggressive rare tumors. Advances in understanding genetic alterations and molecular predictors are crucial for improved diagnosis and prognosis of these adrenal tumors.

More Related Videos

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Related Experiment Videos

Last Updated: Jun 19, 2026

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Area of Science:

  • Endocrinology and Oncology
  • Genetics and Molecular Biology

Context:

  • Adrenocortical carcinomas (ACCs) are rare, aggressive endocrine tumors with poor prognosis.
  • Current treatments are limited, especially for invasive or metastatic disease, due to incomplete understanding of pathogenesis.
  • Histopathology alone is often insufficient for accurate diagnosis and prognosis.

Purpose:

  • To review recent advances in understanding the pathogenesis of adrenocortical tumors.
  • To highlight the development of molecular predictors for malignancy and survival in ACCs.
  • To discuss improvements in the management of adrenocortical tumors.

Summary:

  • Recent research has focused on genetic syndromes and alterations driving ACC development.
  • Molecular predictors show promise for improving diagnostic accuracy and prognostic assessment.
  • Understanding these molecular mechanisms is key to developing effective medical treatments.

Impact:

  • Improved diagnostic capabilities for distinguishing benign from malignant adrenal tumors.
  • Enhanced prognostic accuracy, guiding treatment decisions for adrenocortical carcinoma.
  • Potential for developing novel targeted therapies for aggressive adrenocortical carcinomas.