Association of G1057D variant of insulin receptor substrate-2 with endometriosis
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Filiz Cayan1, Devrim Ertunç, Nurcan Aras-Ateş
1Department of Obstetrics and Gynecology, University of Mersin School of Medicine, Mersin, Turkey. filizcayan@yahoo.com
Objective:
To investigate whether the insulin receptor substrate (IRS)-2 G1057D polymorphism is associated with the risk of endometriosis, and to evaluate potential correlation of IRS2 gene polymorphism with the stages of endometriosis.
Design:
Case-control study.
Setting:
Gynecology clinics in university hospital.
Patient(S):
Women with (n = 135) or without (n = 135) endometriosis. Afterward, the women with endometriosis were divided into two groups according to the stage: group 1 included 63 women in stages I-II, and group 2 included 72 women in stages III-IV.
Intervention(S):
Genotyping by polymerase chain reaction-based restriction fragment-length polymorphism method.
Main Outcome Measure(S):
Genotype distribution of the G1057D polymorphism in the IRS2 gene.
Result(S):
The genotype distribution of the IRS2 G1057D polymorphism in the endometriosis group was significantly different from that of the control group (GG/GD/DD rates were 43.0%/39.3%/17.7% and 55.6%/36.3%/8.1% for the endometriosis and control groups, respectively). Further subgroup analyses according to the stage of endometriosis also revealed a positive association between the IRS2 DD genotype expression and stage III-IV endometriosis patients in the population studied.
Conclusion(S):
These results suggest that the IRS2 G1057D polymorphism may be associated with an increased risk for endometriosis.
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